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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Cancer Res. 2020 Sep 9;80(20):4346–4354. doi: 10.1158/0008-5472.CAN-20-1353

Table 1.

Pancreatic cancer associations for six novel genes that have not been previously reported

Region Gene name* Classificationa R2b No. of SNPs in prediction models Associations based on S-PrediXcan analyses Associations in conditional analyses adjusting for known risk variantsb
OR 95% CI P valuec FDR P value OR 95% CI P value after adjusting for known risk variantsd
6q27 SFT2D1 protein 0.07 3 1.54 1.25 – 1.89 5.40 × 10−5 0.04 1.50 1.18–1.90 9.29 × 10−4
13q12.13 MTMR6 protein 0.25 41 0.78 0.70 – 0.88 4.94 × 10−5 0.04 0.79 0.70–0.90 4.33 × 10−4
14q24.3 ACOT2 protein 0.09 80 1.35 1.17 – 1.56 6.06 × 10−5 0.04 1.40 1.20–1.63 2.22 × 10−5
17q12 STARD3 protein 0.01 11 6.49 2.96 – 14.27 3.59 × 10−6 0.01 5.11 2.10–12.48 3.59 × 10−4
17q21.1 GSDMB protein 0.03 44 1.94 1.45 – 2.58 7.03 × 10−6 0.01 2.09 1.51–2.87 7.64 × 10−6
20p13 ADAM33 protein 0.11 35 1.41 1.20 – 1.66 4.43 × 10−5 0.04 1.44 1.20–1.72 1.10 × 10−4
a

Protein: protein coding genes;

b

R2: prediction performance (R2) derived using GTEx data;

c

P value: derived from association analyses of 8,275 cases and 6,723 controls; associations with FDR-corrected P value ≤ 0.05 considered significant;

d

Adjusted risk SNPs include known pancreatic cancer risk SNPs that are available in current datasets: rs3790844, rs2816938, rs1486134, rs9854771, rs401681, rs2736098, rs35226131, rs6971499, rs17688601, rs78417682, rs1561927, rs10094872, rs2941471, rs505922, rs9543325, rs9581943, rs7190458, rs11655237, rs4795218, rs1517037, and rs16986825.

*

Bold ones represent associations with P < 5.93 × 10−6, based on Bonferroni correction of 8,433 tests (0.05/8,433).