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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Anesthesiology. 2020 Nov 1;133(5):1060–1076. doi: 10.1097/ALN.0000000000003491

Figure 5. Dysregulated transcriptomic responses of local immunity in atelectasis without systemic lipopolysaccharide (LPS) exposure.

Figure 5

(A) Number of differentially expressed genes (absolute fold change>1.5 and Padj<0.05) in atelectatic and aerated lung in LPS(−) or LPS(+) conditions. Up: upregulated; down: downregulated. (B) Network visualization of gene sets in atelectasis vs aerated regions. Node color and darkness indicate the signal and absolute value of normalized enrichment scores in atelectasis: red: positive; blue: negative. Node size represents the false discovery rate adjusted enrichment P-value. Overlap of genes between nodes is indicated by an edge. Immune-related gene sets are highlighted in bold. (C) Gene sets in LPS(−) relevant to immune response negatively enriched in atelectatic vs aerated lung. Node colors represent normalized enrichment score and node sizes represent the number of genes in the set.