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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Anesthesiology. 2020 Nov 1;133(5):1060–1076. doi: 10.1097/ALN.0000000000003491

Figure 8. Association of ISGs with the response of atelectatic tissue to systemic lipopolysaccharide (LPS) exposure.

Figure 8

Enriched transcription factors in the atelectatic vs aerated lung in LPS(−) (A) or LPS(+) (B) conditions. (C) Real-time polymerase chain reaction (PCR) validation showing lower mRNA expression for NF-κB-associated factors CXCL8 and F2RL1 in LPS-unexposed atelectasis (n=6 animals). (D) Volcano plot presenting a large subset of interferon-stimulated genes (ISGs) upregulated in LPS-exposed atelectatic. (E, F) Real-time PCR validation showing mRNA expression for upregulated ISGs (E) and ISGs regulators (F) in the atelectatic vs aerated lung during LPS exposure (n=6 animals). * P<0.05; ** P<0.01; *** P<0.001.