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. Author manuscript; available in PMC: 2021 Mar 21.
Published in final edited form as: Nat Metab. 2020 Sep 21;2(10):1149–1162. doi: 10.1038/s42255-020-00278-3

Extended Data Fig. 2. Lipid profiling and subsequent QTL mapping reveals clusters of associated lipids.

Extended Data Fig. 2

a, Lipid class distribution of all 1,721 plasma and b, 1,562 liver lipidomic features. c, 1,405 plasma and d, 1,190 lipid features showed at least one QTL with an LOD > 6 as displayed in a Manhattan plot (n = 3,353 and 2,269 total QTL, respectively). Hierarchical clustering of these features against the 69,005 markers on the mouse genome, resulted in clustering of lipid class based on hotspots at the genetic level. Abbreviations: Chr (chromosome), DO (diversity outbred), QTL (quantitative trait loci), LOD (logarithm of odds).