Extended Data Fig. 4. B4galnt1 as the candidate gene at the hotspot with the largest LOD.

a, The selection of B4galnt1 as the candidate gene for the chromosome 10:127 Mbp locus was corroborated by NOD-specific allele effects in previously reported liver eQTL and b, pQTL.³⁴ c, The allele effect patterns of the later as gangliosides identified features mapping to the B4galnt1 locus could further be validated in an independent experiment of founder strain mice (exemplar GM3 pattern, n = 4 for each sex and strain, boxplots are defined with the first and third quartiles (25th and 75th percentile) for lower and upper hinges, 1.5x interquartile range for the length of the whiskers, center line at median (50% quantile)). Abbreviations: FS (founder strain), Mbp (megabase pair).