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. Author manuscript; available in PMC: 2021 Sep 5.
Published in final edited form as: Hepatol Int. 2020 Sep 5;14(5):667–676. doi: 10.1007/s12072-020-10082-6

Figure 3: IL-22 and IL-6 mainly activates STAT3 in hepatocytes.

Figure 3:

Both IL-6 and IL-22 mainly induces STAT3 in hepatocytes and subsequently induces transcription of many genes that exert many important functions as indicated in the figure. IL-6 and IL-22 also activate many other signaling pathways (such as STATI, STAT5, AKT, MAPK, AMPK etc) but to a much lesser extent. The action of IL-22 is mediated by binding to the heterodimeric receptors of IL-10R2 and IL-22R1 with the latter one mainly expressed on epithelial cells. The function of IL-6 is mediated by binding to the IL-6R and its signal chain gpl30, both of receptor and signal protein are ubiquitously expressed. Thus IL-6 has much broader effects than IL-22 that mainly targets epithelial cells including hepatocytes.