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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Neurobiol Dis. 2020 Aug 21;145:105058. doi: 10.1016/j.nbd.2020.105058

Figure 3.

Figure 3.

Small RNA modifications in the 30–40-nt fraction from samples of the prefrontal lobe cortex of dementia patients. (A) Representative image showing purification of 30–40-nt small RNAs for the analysis of RNA modifications. (B) Increases in 2’-O-methylcytidine (Cm), 2’-O-methyluridine (Um) and 7-methylguanosine (m7G) modifications, and (C) reductions in 1-methylguanosine (m1G),N2,N2-dimethylguanosine (m2,2G) and pseudouridine (psi or Ψ) modifications in the cortex of AD compared with CONT subjects (each dot in the figure represents value from one independent sample); *P < 0·05 vs. CONT by Student t-test.