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Mode of inhibition determined by kinetics. Reaction rates were measured with 30 nM cdMMP-14 and 1–40 μM FRET peptide substrate M-2350 in the presence of Fabs at various concentrations. With unchanged Vmax and increased apparent Km values, 3A2, 3E2, and DX-2400 exhibited competitive inhibition, while 2B5 and 3D9 were mixed model inhibitors (competitive and uncompetitive).
