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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Drug Discov Today. 2020 Jul 9;25(9):1682–1692. doi: 10.1016/j.drudis.2020.07.004

FIGURE 1.

FIGURE 1

(a) Multitarget drug design strategies based on pharmacophore integration levels; (b) A representative example of noncleavable multitarget-directed ligands (MTDLs); (c) A representative example of cleavable MTDLs; (d) A representative example of fused pharmacophores; (e) A representative example of merged pharmacophores. The parts of structures colored red, blue, and pink represent different pharmacophores conferring corresponding biological activities; the parts in black and purple represent the linker and the merged scaffold between the two pharmacophores, respectively.