Figure 1. Broadly cross-reactive anti-neuraminidase monoclonal antibodies.
(A) Specificities of 21 clonally distinct mAbs, IGHV and IGLV gene usage, and amino acid sequence of the heavy chain CDR3 for each BNA-mAb.
(B) ELISA of binding by seven BNA-mAbs plus an IBV HA-specific mAb (2B04) to recombinant NA and HA from the indicated IBV strains. Data are representative of two experiments. See also Figure S1 and Tables S1 and S2.