Table 3. Expression of SCARF genes in human DRG from bulk RNA sequencing experiments.
Genes are shown with mean +/− standard deviation (SD) expression in TPMs in 3 lumbar DRG samples and 5 thoracic DRG samples. Mouse DRG neuronal expression denotes detection in the neurofilament (NF), peptidergic (PEP), nonpeptidergic (NP) and tyrosine hydroxylase (TH) subsets of DRG neurons. Human DRG data is from [20; 23] and mouse single cell data is from [30]. ND: Not Detectable.
| Human gene | Lumbar DRG (mean +/− SD) TPM | Thoracic DRG (mean +/− SD) TPM | Neuronal expression in mouse DRG? | SCARF Classification |
|---|---|---|---|---|
| ACE2 | 0.09 +/− 0.02 | 0.94 +/− 0.88 | NF | Receptors |
| BSG | 304.82 +/− 82.3 | 239.42 +/− 79.23 | PEP, NP, NF, TH | Receptors |
| ANPEP | 14.56 +/− 7.27 | 13.73 +/− 4.26 | PEP, TH | Receptors |
| CD209 | 0.57 +/− 0.43 | 1.60 +/− 1.28 | Multiple mouse orthologs | Receptors |
| CLEC4G | 0.79 +/− 0.34 | 0.22 +/− 0.45 | ND | Receptors |
| CLEC4M | 0.02 +/− 0.03 | 0.19 +/− 0.17 | No ortholog | Receptors |
| DPP4 | 0.34 +/− 0.23 | 3.75 +/− 4.05 | ND | Receptors |
| TMPRSS2 | 3.05 +/− 1.04 | 6.69 +/− 2.65 | NF, TH | Proteases |
| TMPRSS11A | ND | 0.06 +/− 0.13 | NF, TH | Proteases |
| TMPRSS11B | ND | 0.03 +/− 0.04 | No ortholog | Proteases |
| FURIN | 20.86 +/− 5.69 | 34.11 +/− 10.44 | PEP, NP, NF, TH | Proteases |
| TMPRSS4 | 0.77 +/− 0.30 | 0.08 +/− 0.09 | NF | Proteases |
| CTSL | 154.53 +/− 21.71 | 105.19 +/− 13.36 | PEP, NP, NF, TH | Proteases |
| CTSB | 1116.17 +/− 132.45 | 697.50 +/− 96.96 | PEP, NP, NF, TH | Proteases |
| TOP3B | 6.46 +/− 0.88 | 18.93 +/− 5.45 | PEP, NP, NF, TH | Replication Factors |
| MADP1 | 35.13 +/− 8.08 | 32.74 +/− 7.44 | PEP, NP, NF, TH | Replication Factors |
| LY6E | 446.65 +/− 234.34 | 218.17 +/− 161.15 | PEP, NP, NF, TH | Restriction Factors |
| IFITM1 | 828.53 +/− 425.04 | 322.86 +/− 104.16 | PEP, NP, NF, TH | Restriction Factors |
| IFITM2 | 880.05 +/− 340.01 | 2241.85 +/− 91.24 | PEP, NP, NF, TH | Restriction Factors |
| IFITM3 | 2339.37 +/− 943.43 | 744.00 +/− 224.85 | PEP, NP, NF, TH | Restriction Factors |
| CALCA | 1634.46 +/− 665.44 | 524.86 +/− 111.60 | PEP, NP, NF, TH | Neuronal Markers |
| P2RX3 | 44.65 +/− 42.69 | 144.54 +/− 47.60 | PEP, NP, NF, TH | Neuronal Markers |
| NPPB | 41.20 +/− 16.37 | 21.29 +/− 8.99 | NP, PEP | Neuronal Markers |
| MRGPRD | 3.01 +/− 4.62 | 10.47 +/− 7.64 | PEP, NP, NF, TH | Neuronal Markers |