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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Toxicol In Vitro. 2020 Sep 2;69:104991. doi: 10.1016/j.tiv.2020.104991

Figure 2. Pathway enrichment analysis of differentially regulated genes by PAH and PAH mixture exposure.

Figure 2.

Functional enrichment analysis was performed in MetaCore (GeneGO, Thomson Reuters) based on mapping of the significant (p<0.05) genes in each treatment group onto built-in functional network processes. Heatmap visualizing the top 30 most differentially significant process networks (greatest std(−logpval) regulated by 7 PAH treatments (p<0.01 for at least one PAH group). Values are pval that have been transformed (−logpvalue) for pathway enrichment of treatments, where blue, white, and yellow represent −logpvalue = 0, 1.3 (p<0.05), and 2.0 (p<0.01), respectively.