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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Pancreatology. 2020 Sep 3;20(7):1413–1420. doi: 10.1016/j.pan.2020.08.016

Fig. 2. Proposed effects of zinc-deficiency on pancreatitis responses.

Fig. 2.

(A) Model of acute pancreatitis in with normal (Sufficiency) zinc levels; (B) Potential effects of zinc depletion (Deficiency) on acinar cell pancreatitis responses. HMGB1 = High mobility group box 1 protein; nDNA = normal DNA; mtDNA = mitochondrial DNA; Hsp = heat shock protein; Ab = antibody; DAMPs = damage-associated molecular patterns; TRPV4 = transient receptor potential cation channel subfamily V Member 4; PLA2 = phospholipase A2; Piezo1 = piezo type mechanosensitive ion channel component 1; Orai1 = calcium release-activated calcium modulator 1; RER = rough endoplasmic reticulum; SER = smooth endoplasmic reticulum; Ryr = ryanodine receptor; PMCA4b = plasma membrane calcium-transporting ATPase 4; NLRP3 = NLR family pyrin domain containing 3; Zip8 = Zrt-Irt-like protein 8; GPR39 = G-protein coupled receptor 39.