Table 2.
cis eQTLs in GWAS CAD SNPs in the vicinity of ZEB2 in STARNET (p < 0.05 is considered statistically significant).
SNP id | SNP chromosome location | Reference allele | CAD risk allele | Tissue | Target gene name | Beta | p value | FDR | GTEx p value | GTEx eQTL tissue |
---|---|---|---|---|---|---|---|---|---|---|
rs1830321 | chr2:145067988 | C | T | AOR | ZEB2 | 0.1727 | 0.00697 | 0.8931 | 0.0001 | Aorta |
rs1830321 | chr2:145067988 | C | T | SF | TEX41 | −0.1916 | 0.00199 | 0.4918 | - | - |
rs6740731 | chr2:144513025 | G | A/C/T | MAM | AC009951.1 | 0.2425 | 0.00445 | 0.7921 | 0.000011 | Skelet. mu |
rs17678683 | chr2:144528992 | T | G | AOR | GTDC1 | −0.2844 | 0.00879 | 0.9435 | 0.0000012 | Skelet. mu |
rs17678683 | chr2:144528992 | T | G | VAF | ZEB2 | 0.2920 | 0.00994 | 0.9530 | - | |
rs17678683 | chr2:144528992 | T | G | SF | ZEB2 | 0.3380 | 0.00180 | 0.4978 | - |
There were no cis eQTLs identified for rs2252641. These results are also presented in Figure 2. The final 2 columns are data derived from the GTEx study for the same SNPs/eQTLs. Skelet. Mu, skeletal muscle.