Table 2:

Effects of prior concussion on variables of interest

Clinical measures	Main Effect	Contrast	MD	Std. Error	95 % CI	p
Symp. Sev. Score	χ2(2)=8.93, p=0.012	0 vs. 1	0.16	0.31	−0.44, 0.77	0.60
		0 vs. 2+	−0.81	0.31	−1.41, −0.12	0.01
		1 vs. 2+	−0.97	0.36	−1.68, −0.26	0.01
BSI-GSI	χ2(2)=5.95, p=0.051	0 vs. 1	−0.03	0.29	−0.60, 0.54	0.92
		0 vs. 2+	−0.69	0.30	−1.27, −0.11	0.02
		1 vs. 2+	−0.66	0.34	−1.33, 0.01	0.05
ImPACT-Memory	χ2(2)=0.52, p=0.77	0 vs. 1	−0.04	0.17	−0.38, 0.29	0.79
		0 vs. 2+	0.10	0.18	−0.25, 0.44	0.58
		1 vs. 2+	0.14	0.20	−0.25, 0.54	0.48
ImPACT-Speed	χ2(2)=0.50, p=0.78	0 vs. 1	−0.01	0.16	−0.32, 0.29	0.94
		0 vs. 2+	0.10	0.16	−0.21, 0.42	0.52
		1 vs. 2+	0.12	0.18	−0.25, 0.48	0.53
Baseline Inflammatory markers
CRP	χ2(2)=0.11, p=0.94	0 vs. 1	−0.09	0.29	−0.67, 0.48	0.76
		0 vs. 2+	0.01	0.30	−0.58, 0.60	0.98
		1 vs. 2+	0.10	0.35	−0.58, 0.78	0.78
IL-6	χ2(2)=0.83, p=0.66	0 vs. 1	0.03	0.14	−0.24, 0.31	0.82
		0 vs. 2+	−0.11	0.15	−0.40, 0.18	0.44
		1 vs. 2+	−0.14	0.17	−0.47, 0.19	0.39
IL-1RA	χ2(2)=1.89, p=0.39	0 vs. 1	−0.02	0.10	−0.22, 0.18	0.86
		0 vs. 2+	−0.14	0.10	−0.34, 0.06	0.19
		1 vs. 2+	−0.12	0.12	−0.36, 0.11	0.31
Subcortical Volume
Hippocampus	F(2, 192.01)=0.66, p=0.52	0 vs. 1	153.30	153.39	−149.24, 455.85	0.32
		0 vs. 2+	141.61	160.21	−174.38, 457.60	0.38
		1 vs. 2+	−11.69	179.48	−365.70, 342.32	0.95

Note: MD = estimated marginal mean difference, SE = standard error; CI = confidence interval, Symp. Sev. Score= SCAT-3 Symptom Severity Score, BSI-GSI = Brief Symptom Inventory Global Severity Index, C-reactive Protein (CRP), IL = interleukin, RA = receptor antagonist. Natural log-transformed values of inflammatory markers are presented (pg/mL). Symp. Sev. Score and BSI-GSI values obtained from the conducted negative binomial models with log link transformed are presented. Hippocampal volumes are presented in mm³. The lower and upper levels of quantification for markers in pg/mL are as follows: IL-1RA, 0.17-5.14 and 732-1,150; IL-6, 0.006-0.26 and 721-764; CRP, 1.11-4.62 and 202,000.