Table 4.
Average adjusted 10-year change in left ventricular structure associated with number of valve sites with calcification progression: MESA.
| No progression | One site only (AVC or MAC) | Two sites (AVC and MAC) | p-for-trend | |
|---|---|---|---|---|
| N (row %) | 2385 (86.8%) | 311 (11.3%) | 52 (1.9%) | 2748 |
| Left ventricular mass-to-volume ratio | ||||
| Model 1 | Ref = 0 | 3.45 (0.79, 6.10) | 5.09 (−1.09, 11.28) | 0.004 |
| Model 2 | Ref = 0 | 3.45 (0.79, 6.11) | 5.08 (−1.11, 11.26) | 0.004 |
| Model 3 | Ref = 0 | 3.45 (0.79, 6.11) | 5.07 (−1.11, 11.26) | 0.004 |
| Model 4 | Ref = 0 | 3.45 (0.79, 6.11) | 5.07 (−1.11, 11.26) | 0.004 |
| Left ventricular mass | ||||
| Model 1 | Ref = 0 | 1.26 (0.05, 2.47) | 0.86 (−1.96, 3.68) | 0.06 |
| Model 2 | Ref = 0 | 1.26 (0.05, 2.47) | 0.85 (−1.97, 3.67) | 0.06 |
| Model 3 | Ref = 0 | 1.25 (0.04, 2.46) | 0.86 (−1.96, 3.68) | 0.06 |
| Model 4 | Ref = 0 | 1.25 (0.04, 2.46) | 0.86 (−1.96, 3.68) | 0.06 |
| Left ventricular end diastolic volume | ||||
| Model 1 | Ref = 0 | −0.13 (−1.63, 1.36) | −0.87 (−4.36, 2.61) | 0.66 |
| Model 2 | Ref = 0 | −0.13 (−1.63, 1.36) | −0.87 (−4.36, 2.61) | 0.66 |
| Model 3 | Ref = 0 | −0.13 (−1.63, 1.36) | −0.88 (−4.36, 2.61) | 0.66 |
| Model 4 | Ref = 0 | −0.13 (−1.63, 1.36) | −0.88 (−4.36, 2.61) | 0.66 |
| Left ventricular end systolic volume | ||||
| Model 1 | Ref = 0 | 1.35 (0.45, 2.25) | −0.40 (−2.50, 1.70) | 0.05 |
| Model 2 | Ref = 0 | 1.35 (0.45, 2.25) | −0.40 ( 2.50, 1.70) | 0.05 |
| Model 3 | Ref = 0 | 1.35 (0.45, 2.25) | −0.40 (−2.50, 1.70) | 0.05 |
| Model 4 | Ref = 0 | 1.35 (0.45, 2.25) | −0.40 (−2.50, 1.70) | 0.05 |
| Left ventricular stroke volume | ||||
| Model 1 | Ref = 0 | −3.66 (−5.77, −1.55) | −2.07 (−6.99, 2.85) | 0.002 |
| Model 2 | Ref = 0 | −3.67 (−5.78, −1.56) | −2.05 (−6.98, 2.87) | 0.002 |
| Model 3 | Ref = 0 | −3.68 (−5.79, −1.57) | −2.07 (−6.99, 2.85) | 0.002 |
| Model 4 | Ref = 0 | −3.68 (−5.79, −1.57) | −2.07 (−6.99, 2.85) | 0.002 |
| Left ventricular ejection fraction | ||||
| Model 1 | Ref = 0 | −1.78 (−2.72, −0.83) | 0.01 (−2.18, 2.21) | 0.01 |
| Model 2 | Ref = 0 | −1.78 (−2.72, −0.83) | 0.02 (−2.18, 2.21) | 0.01 |
| Model 3 | Ref = 0 | −1.78 (−2.72, −0.84) | 0.01 (−2.18, 2.21) | 0.01 |
| Model 4 | Ref = 0 | −1.78 (−2.72, −0.84) | 0.01 (−2.18, 2.21) | 0.01 |
Values in bold font are statistically significant, p<0.05
Model 1: age, race/ethnicity, sex, MESA site, CT scanner type, and time between baseline & follow-up CT
Model 2: Model 1+ educational status, BMI, smoking status, pack-years of smoking, & physical activity
Model 3: Model 2 + systolic blood pressure, use of antihypertensives, use of lipid lowering medications, total cholesterol, HDL-cholesterol, diabetes status & eGFR
Model 4: Model 3 + baseline coronary calcium