Fig. 3.

White-matter involvement in sporadic ALS revealed by a multi-site DTI study. FA decreases were found along the corticospinal tracts, frontal lobe, brainstem and hippocampi. Red circles indicate deficits only significant with correction for site differences. ALS, amyotrophic lateral sclerosis; WBSS, whole-brain-based spatial statistics; FA, fractional anisotropy; FDR, false discovery rate. Adapted from Müller et al. (2016) with permission from BMJ Publishing Group Ltd.