Table 3.

Non-structural proteins of SARS-CoV-2 and their functions (20).

Non-structural proteins	Functions
Nsp1	Host mRNA degradation, inhibit IFN signal
Nsp2	N/A
Nsp3	Polyprotein processing via papain-like protease, Structure TM domain, inhibits ubiquitination; DMV?
Nsp4	DMV formation? TM domain
Nsp5	Polyprotein processing via 3C-like proteinase
Nsp6	DMV formation? TM domain
Nsp7	Single-stranded RNA binding
Nsp8	Primase
Nsp9	Component of replicase complex
Nsp10	Component of replicase complex
Nsp11	N/A
Nsp12	RNA dependent RNA polymerase
Nsp13	Helicase action, ZBD
Nsp14	Exoribonuclease activity, 5'-cap formation (N-7-methyltransferase)
Nsp15	Endoribonuclease activity
Nsp16	5'-cap formation (2-O-methyltransferase)