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. 2020 Oct 6;11:580378. doi: 10.3389/fimmu.2020.580378

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Copyright © 2020 Chen, Liu, Liu, Zhou, He and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The agonists and antagonists of Y receptors. (A) NPY and PYY are processed into different ligands. Although these ligands have a similar amino acid composition to NPY/PYY, when the two amino acid residues of NPY/PYY are replaced or truncated, it significantly changes their affinity for different Y receptor subtypes. (B) The most commonly used agonists and antagonists specific for different Y receptor subtypes. NPY, neuropeptide Y; PYY, peptide YY; Tyr, Tyrosine; Leu, Leucine; Pro, Proline; Ala, Alanine; Aib, 2-aminoisobutyric acid.