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. 2020 Oct 6;11:580378. doi: 10.3389/fimmu.2020.580378

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Copyright © 2020 Chen, Liu, Liu, Zhou, He and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NPY directly regulates immune cells. NPY of the immune system derived from the secretion of the sympathetic nervous system, tissue structure cells, and immune cells. NPY plays multiple roles in immune cells, including via Y1R inhibiting activation and regulation of proliferation, differentiation, and cytokine secretion; via Y1R/Y2R/Y5R mediating phagocytosis and migration. Among these, Y1R has a bimodal effect on the immune system, showing both anti-inflammatory properties and specific pro-inflammatory effects. In addition, the Y1R mainly mediates the promotion of NPY, while the Y2/Y5 receptor mediates the inhibition of NPY. Therefore, the interaction of Y1R and Y2/Y5R is involved in the regulation of immune cells. In this figure, NPY receptor symbols on different immune cells symbolize their involvement in the diverse functional regulation of NPY. NK, natural killer; NPY, neuropeptide Y; SNS, sympathetic nervous system.