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. 2020 Oct 6;10:575656. doi: 10.3389/fcimb.2020.575656

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Copyright © 2020 Baraniya, Jain, Lucarelli, Tam, Vanderveer, Puri, Yang and Al-hebshi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Catalase inhibits cytotoxicity of S. mitis against oral cancer cell lines. (A) CAL27, SCC25, SCC4, and TIGKs (as non-cancer control) were cocultured with S. mitis at MOIs of 10, 50, and 100 and counting performed at 24, 48, and 72 h. ^¶Statistically significant (p ≤ 0.05) for MOI 50 and 100 compared to the control; ^#for MOI 100 only. (B) CAL27 cocultured with S. mitis at MOI 100 in the presence or absence of exogenous catalase at 20 or 200 U. *Statistically significant (p ≤ 0.05) for all treatments compared to the control; ^#for MOI 100 treatment without catalase. (C) Same as for (B) but using the lysate at 400 μg/ml instead. *Statistically significant for all treatments compared to the control; ^#for 400 μg/ml lysate treatment without catalase.