Table 2.
Wheel Activity
| B6-W | MIN-W | Body Weight | Lean Mass | Time to Fatigue | Grip Strength | |
|---|---|---|---|---|---|---|
| Distance on Wheel (km) | Correlation to MIN-W Distance on Wheel (R) | |||||
| Total | 127.4 ± 7.8 | 103.4 ± 15.3 | 0.32 | 0.43 | 0.12 | −0.20 |
| Week 1 | 20.4 ± 1.1 | 18.1 ± 2.2 | 0.00 | 0.09 | −0.17 | −0.25 |
| Week 5 | 25.1 ± 1.8 | 15.2 ± 2.6* | 0.25 | 0.75# | 0.25 | 0.10 |
| Time on Wheel (min/day) | Correlation to MIN-W Time on Wheel (R) | |||||
| Total | 147.0 ± 7.6 | 112.6 ± 14.7* | 0.30 | 0.37 | 0.10 | −0.14 |
| Week 1 | 119.1 ± 11.1 | 107.7 ± 12.1 | −0.24 | −0.17 | −0.19 | −0.29 |
| Week 5 | 149.0 ± 15.0 | 76.2 ± 15.9* | 0.44 | 0.48 | 0.06 | 0.04 |
| Average Speed (km/hr) | Correlation to MIN-W Average Speed (R) | |||||
| Total | 1.53 ± 0.02 | 1.41 ± 0.03* | 0.12 | 0.07 | 0.30 | −0.52 |
| Week 1 | 1.40 ± 0.19 | 1.34 ± 0.02 | −0.25 | −0.30 | −0.27 | −0.44 |
| Week 5 | 1.58 ± 0.05 | 1.44 ± 0.03* | 0.41 | 0.28 | 0.41 | 0.00 |
| Maximal Speed (km/hr) | Correlation to MIN-W Maximal Speed (R) | |||||
| Total | 2.31 ± 0.12 | 2.17 ± 0.11 | 0.03 | 0.37 | 0.38 | −0.37 |
| Week 1 | 2.10 ± 0.19 | 2.25 ± 0.26 | 0.13 | −0.28 | −0.18 | −0.02 |
| Week 5 | 2.20 ± 0.06 | 1.96 ± 0.09* | 0.74# | 0.31 | 0.28 | 0.02 |
Values are means ± SEM and Pearson’s correlation (R). C57BL/6 (B6). ApcMin/+ (MIN). Wheel access (W; B6-W n=9, MIN-W n=10). Correlations were between each wheel measurement and the percent change between 12 and 18 weeks on compositional and functional outcomes in MIN-W. Two-way ANOVA.
*
Main effect of genotype.
^
Main effect of treatment.
$
Repeated measures, effect of time.
#
Significant correlation. Significance was set a p≤0.05