Table 2.

Association of tag SNPs on fatty acid biosynthesis genes with multiple sclerosis risk

			MS Sunshine Study					Replication Dataset
			Crude*	Adjusted OR (95% CI)***				Adjusted OR (95% CI)****
Gene	SNP	major/minor allele	p value	OR	95% CI		p value	OR	95% CI		p value
FADS1	rs174548**	C/G	0.13	0.88	0.73	1.05	0.15	nt
ELOVL2	rs3734398**	T/C	0.41	0.96	0.80	1.14	0.63	nt
FADS2	rs968567**	C/T	0.21	0.82	0.63	1.07	0.15	nt
	rs99780**	C/T	0.15	0.89	0.74	1.06	0.18	nt
	rs174570**	C/T	0.39	0.96	0.76	1.21	0.71	nt
	rs174575**	C/G	0.91	1.01	0.83	1.22	0.95	nt
	rs2727271**	A/T	0.20	0.89	0.69	1.14	0.35	nt
	rs498793**	C/T	0.96	1.00	0.85	1.19	0.96	nt
	rs93923	C/T	0.85	0.99	0.80	1.24	0.96	nt
	rs2851682	A/G	0.0269	0.77	0.59	1.00	0.05	nt
	rs174592	A/G	0.79	1.00	0.83	1.19	0.96	nt
	rs174593	T/C	0.71	1.04	0.86	1.26	0.71	nt
	rs174611	T/C	0.0063	0.74	0.60	0.92	0.0056	0.83	0.70	0.98	0.0287
	rs174618	T/C	0.0162	0.79	0.66	0.94	0.0090	0.86	0.74	1.01	0.0651
	rs639394	A/G	0.59	0.95	0.69	1.31	0.76	nt
	rs34013632	GT/G	0.55	0.93	0.71	1.22	0.61	nt
	rs174622	G/A	0.0288	0.77	0.62	0.96	0.0206	0.95	0.78	1.17	0.6587
	rs11539526	C/T	0.33	0.87	0.67	1.13	0.29	nt

^*additive genetic model, the OR measures the change in odds of having MS associated with carrying each one copy of the minor allele compared to the major allele

^**a priori tag SNPs selected from published literature

^***adjusted for age at index date, sex, HLA-DRB1*15:01 status, genetic ancestry, and smoking

^***adjusted for age at index date, sex, HLA-DRB1*15:01 status and genetic ancestry

Abbreviations: fatty acid desaturase 1 and 2 (FADS1, FADS2), elongation of very long-chain fatty acids 2 (ELOV2), SNP single nucleotide polymorphisms, OR=odds ratio, CI=confidence interval, nt=not tested