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. 2020 Oct 6;11:573429. doi: 10.3389/fgene.2020.573429

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Copyright © 2020 Huang, Zheng, Yin, Lu, Li, Liang, Hu, Bi, Zhan, Xue, Jiang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subpopulations of epithelial cells and reconstructing the developmental trajectory of epithelial cells. (A) Violin plots showing the expression of marker genes in each cluster of epithelial cells. (B,C) tSNE and UMAP plots showing all the epithelial cell subtypes distribution. (D) Pseudotemporal trajectory of seven subtype cells. (E) The gradual change from black to light blue indicates the change of pseudotime. (F) The pseudotime trajectory showed epithelial cells with five different states. (G) The trajectory showing the subtype cells come from four lung samples. (H) The trajectory showing the phase distribution of all cells in different branches. (I) According to the changes of gene expression in pseudotime, the top six genes that may affect the fate of cells were shown. (J) Heatmap showed the top 50 genes that affect cell fate decisions. The 50 genes were divided into five clusters.