. 2020 Oct 6;11:554679. doi: 10.3389/fphys.2020.554679

TABLE 4.

ANOVA results of responses during the modified high-dose methacholine challenge.

	CA vs. CVA	CA vs. Cough	CA vs. Control	CVA vs. Cough	CVA vs. Control	Cough vs. Control	P-value
Sensory responses
Cough frequency	0.001	0.004			0.001	0.006	< 0.001
Borg overall			0.010			0.029	0.004
Spirometry
%ΔFEV₁		0.033	< 0.001		0.001		< 0.001
ΔFEV₁ (%pr)			0.006				0.006
ΔFVC (%pr)		0.005	< 0.001		0.001		< 0.001
ΔFEV₁/FVC (%pr)					0.005		0.005
ΔFEF₂₅_–_75% (%pr)							0.303
Lung volumes
ΔTLC (%pr)							0.854
ΔRV (%pr)	0.023	0.002	< 0.001				< 0.001
ΔRV/TLC (%pr)	0.038	0.002	< 0.001				< 0.001
ΔIC (%pr)			0.057				0.054
Impulse oscillometry
ΔR5 (cmH₂O/L/s)							0.971
ΔR20 (cmH₂O/L/s)		0.034	0.002		0.010		< 0.001
ΔR5–R20 (cmH₂O/L/s)			0.002				< 0.001
ΔX5 (cmH₂O/L/s)		0.008	0.001	0.033	0.003		< 0.001
ΔAX (cmH₂O/L)		0.022	0.006	0.011	0.002		0.002
ΔFres (Hz)							0.343

Δ = change from baseline to MAX. Bonferroni corrected p-values located within columns represent the significance between groups. Blank spaces represent non-significant differences between groups. Bolded values indicate significant differences. For the definitions of abbreviations, see Table 1.