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. 2020 Oct 6;8:573487. doi: 10.3389/fcell.2020.573487

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Copyright © 2020 Iwata, Wu, Ferdousi, Sasaki, Tominaga, Uchida, Arai, Szele and Isoda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of proliferation and differentiation markers in the hippocampal SGZ. (A) Representative images of immunolabeling for BrdU, DCX, and GFAP in SAMR1 mice given water, SAMP8 mice given water and SAMP8 mice given STEE. Scale bar: 100 μm. (B) Total number of BrdU positive proliferating cells in the SGZ of animals. (C) Number of DCX/BrdU double-positive newborn immature neurons. (D) Number of GFAP/BrdU double-positive cycling astrocytic stem cells and progenitors. The error bar represents the ± SEM (n = 3 animals per group). Comparisons were performed through one-way ANOVA with Fisher’s LSD test.