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. 2020 Oct 6;11:581616. doi: 10.3389/fimmu.2020.581616

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Copyright © 2020 De Francesco, Sabin, Reiss and Kootstra

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Partial least squares regression (PLSR) to predict age advancement with monocyte markers in the three study groups combined. (A) Scatter plot of the PLSR score obtained and age advancement. Green circle: People with HIV; Bleu square: COBRA HIV-negative individuals; Red diamond: Blood donors. (B) Variable Importance in Projection (VIP) values for each monocyte marker. A negative VIP indicates that decreased levels of the specific marker is associated with increased age advancement. A positive VIP indicates that increased levels of the specific markers is associated with increased age advancement.