Skip to main content
. 2020 Oct 6;13:567430. doi: 10.3389/fnmol.2020.567430

FIGURE 4.

FIGURE 4

P2X7R altered intron retention in HD striatum. (A) Percentage of spliced in (PSI) values for P2X7R intron 10–11 retention in control and HD according to Vast-tools analysis (ΔPSI = 39%). Student’s t-test. *p < 0.05. (B) P2X7R intron 10–11 inclusion level percentage (IncLev%) for control and HD according to rMATS analysis (IncLevDiff% = 41%). *FDR < 0.05. (C) Semi-qRT-PCR directed to P2X7R intron 10–11, represented as the ratio between intron retaining/non-retaining transcripts, confirms increased retention in independent HD cases (CTRL n = 5, HD n = 6). Student’s t-test. **p < 0.01. Graphs show mean ± sem. Dots represent individual values.