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. 2020 Oct 6;7:586146. doi: 10.3389/fmolb.2020.586146

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Copyright © 2020 Jovanović, Dragoj, Zhukovsky, Dar’in, Krasavin, Pešić and Podolski-Renić.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunostaining of proteins ASK1, RNR, and TrxR1 in C6, RC6, U87, and U87-TxR cell lines. Changes in expression of proteins in cells treated with 2 μM 5 and 8 μM 6 are compared to untreated control (set at 100%, red line). All results represent mean values ± SD, obtained from three independent experiments (n = 3). p < 0.05 (*), p < 0.01 (**), and p < 0.0001 (****) indicate significantly different levels of expression in cells treated with compound 5 in comparison with untreated control. p < 0.05 (#) and p < 0.001 (###) indicate statistical significance between untreated control and cells treated with 6.