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. 2020 Oct 6;7:586146. doi: 10.3389/fmolb.2020.586146

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Copyright © 2020 Jovanović, Dragoj, Zhukovsky, Dar’in, Krasavin, Pešić and Podolski-Renić.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5 and 6 inhibit P-gp function and enhance the sensitivity of U87-TxR cells to PTX. (A) Flow cytometric profile of Rho123 accumulation in untreated U87 and U87-TxR cells and U87-TxR cells treated with 1 μM 5, 5 μM 6, and TQ as positive control. (B) Relative reversal of PTX resistance in combination with subinhibitory concentrations of 5 and 6 in the U87-TxR cell line. Statistical significance to PTX alone: p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), and p < 0.0001 (****), and PTX in combination with 0.5 and 1 μM: p < 0.05 (#).