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PDGFRβ regulates TGFβ-induced fibronectin and collagen I (α2). Mesangial cells treated with JNJ (panels A and B) or transfected with siRNAs against PDGFRβ or scrambled RNA (panels C and D) or siRNAs against PDGF B (panels E and F) or myr-Akt and PRAS40 (panels G and H) and incubated with TGFβ for 24 h. The cleared cell lysates were immunoblotted with the indicated antibodies.
