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PDGFRβ regulates TGFβ-induced Akt/PRAS40-mediated mTORC1 activation. A, mesangial cells were transfected with siRNAs against PDGFRβ or scrambled RNA or HA-tagged myr-Akt and PRAS40 (Thr-246A) mutant expression vectors as indicated. Transfected cells were incubated with 2 ng/ml TGFβ. The cleared cell lysates were immunoblotted with indicated antibodies.
