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. 2020 Oct 6;11:580399. doi: 10.3389/fmicb.2020.580399

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Copyright © 2020 Dong, Yang, Wang, Martin, Demczuk and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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penA gene phylogeny, patterns of antimicrobial resistance, and genetic polymorphisms of 124 N. gonorrhoeae isolates. Left: Phylogenetic reconstruction of 124 isolates based on the penA gene and using the maximum likelihood. The red arrow indicates reference strain FA1090. Heatmap. Columns 1 and 2: MIC values of CRO and CFM. Columns 3–5: Susceptible/resistant categories according to the EUCAST MIC breakpoints of CRO, CFM, and ESCs. Column 6: Any mosaic penA allele. Column 7: penA alleles. Columns 8–22: Non-synonymous amino acid changes from wild type in PenA. The purple rectangle indicates clade C as described in the text. The yellow rectangle indicates substitutions in the mosaic penA coding region. Sequence names are colored by cluster.