TABLE 2.
VarElect aggregated score obtained analyzing groups 1, 2, and 4 (G124; 15 top-ranking genes).
| Aggregated score (normalized) | Gene | Gene description | Protein class | Biological process | Molecular function | Disease involvement | Subcellular Location |
| 0.999501151 | TNF | Tumor necrosis factor | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins | Cytokine | Cancer-related genes, FDA approved drug targets | Secreted | |
| 0.624534796 | TNFRSF1A | TNF receptor superfamily member 1A | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins | Apoptosis, Host-virus interaction | Receptor | Amyloidosis, Cancer-related genes, Disease mutation, FDA approved drug targets | |
| 0.529423274 | TP53 | Tumor protein p53 | Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters | Apoptosis,Biological rhythms, Cell cycle, Host-virus interaction, Necrosis, Transcription, Transcription regulation | Activator, DNA-binding, Repressor | Cancer-related genes, Disease mutation, Li-Fraumeni syndrome, Tumor suppressor | Nucleoplasm |
| 0.479435236 | NLRP3 | NLR family pyrin domain containing 3 | Cancer-related genes, Disease related genes, Predicted intracellular proteins | Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation | Activator | Amyloidosis, Cancer-related genes, Deafness, Disease mutation, Non-syndromic deafness | |
| 0.406134194 | TGFB1 | Transforming growth factor beta 1 | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins | Growth factor, Mitogen | Cancer-related genes, Disease mutation | Golgi apparatus, secreted | |
| 0.404538712 | EGFR | Epidermal growth factor receptor | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins | Host-virus interaction | Developmental protein, Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase | Cancer-related genes, Disease mutation, FDA approved drug targets, Proto-oncogene | Plasma membrane |
| 0.393038016 | ICAM1 | Intercellular adhesion molecule 1 | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins | Cell adhesion, Host-virus interaction | Host cell receptor for virus entry, Receptor | Cancer-related genes, FDA approved drug targets | Plasma membrane |
| 0.37555677 | FAS | Fas cell surface death receptor | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Predicted membrane proteins, Predicted secreted proteins | Apoptosis | Calmodulin-binding, Receptor | Cancer-related genes, Disease mutation | Plasma membrane |
| 0.352296 | STAT3 | Signal transducer and activator of transcription 3 | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors | Host-virus interaction, Transcription, Transcription regulation | Activator, DNA-binding | Cancer-related genes, Diabetes mellitus, Disease mutation, Dwarfism | Nucleoplasm, cytosol |
| 0.337175731 | STAT1 | Signal transducer and activator of transcription 1 | Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors | Antiviral defense, Host-virus interaction, Transcription, Transcription regulation | Activator, DNA-binding | Disease mutation | Nucleoplasm, cytosol |
| 0.336625898 | KRAS | KRAS proto-oncogene, GTPase | Cancer-related genes, Disease related genes, Predicted intracellular proteins, RAS pathway related proteins | Cancer-related genes, Cardiomyopathy, Deafness, Disease mutation, Ectodermal dysplasia, Mental retardation, Proto-oncogene | Cytosol | ||
| 0.324061896 | CTNNB1 | Catenin beta 1 | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins | Cell adhesion, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation, Wnt signaling pathway | Activator | Cancer-related genes, Disease mutation, Mental retardation | Plasma membrane |
| 0.315947057 | AKT1 | AKT serine/threonine kinase 1 | Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins | Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Neurogenesis, Sugar transport, Translation regulation, Transport | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase | Cancer-related genes, Disease mutation, Proto-oncogene | Nucleoplasm |
| 0.314911716 | CCND1 | Cyclin D1 | Cancer-related genes, Disease related genes, FDA approved drug targets, Predicted intracellular proteins | Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation | Cyclin, Repressor | Cancer-related genes, FDA approved drug targets, Proto-oncogene | Nucleoplasm |
| 0.312644606 | ERBB2 | Erb-b2 receptor tyrosine kinase 2 | Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins | Transcription, Transcription regulation | Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase | Cancer-related genes, FDA approved drug targets | Plasma membrane |