TABLE 3.
VarElect aggregated score obtained analyzing groups 1, 2, 3, 4, and 5 (G12345; 15 top-ranking genes).
| Aggregated score (normalized) | Gene | Gene description | Protein class | Biological process | Molecular function | Disease involvement | Subcellular Location |
| 0.999992851 | TNF | Tumor necrosis factor | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins | Cytokine | Cancer-related genes, FDA approved drug targets | ||
| 0.646667342 | TNFRSF1A | TNF receptor superfamily member 1A | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins | Apoptosis, Host-virus interaction | Receptor | Amyloidosis, Cancer-related genes, Disease mutation, FDA approved drug targets | |
| 0.469465581 | TP53 | Tumor protein p53 | Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters | Apoptosis, Biological rhythms, Cell cycle, Host-virus interaction, Necrosis, Transcription, Transcription regulation | Activator, DNA-binding, Repressor | Cancer-related genes, Disease mutation, Li-Fraumeni syndrome, Tumor suppressor | Nucleoplasm |
| 0.415888546 | TGFB1 | Transforming growth factor beta 1 | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins | Growth factor, Mitogen | Cancer-related genes, Disease mutation | Golgi apparatus, Cytosol | |
| 0.413794221 | NLRP3 | NLR family pyrin domain containing 3 | Cancer-related genes, Disease related genes, Predicted intracellular proteins | Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation | Activator | Amyloidosis, Cancer-related genes, Deafness, Disease mutation, Non-syndromic deafness | |
| 0.374658935 | FAS | Fas cell surface death receptor | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Predicted membrane proteins, Predicted secreted proteins | Apoptosis | Calmodulin-binding, Receptor | Cancer-related genes, Disease mutation | Plasma membrane |
| 0.332023563 | STAT1 | Signal transducer and activator of transcription 1 | Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors | Antiviral defense, Host-virus interaction, Transcription, Transcription regulation | Activator, DNA-binding | Disease mutation | Nucleoplasm, Cytosol |
| 0.330861395 | ICAM1 | Intercellular adhesion molecule 1 | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins | Cell adhesion, Host-virus interaction | Host cell receptor for virus entry, Receptor | Cancer-related genes, FDA approved drug targets | Plasma membrane, Cytosol |
| 0.325734154 | STAT3 | Signal transducer and activator of transcription 2 | Disease related genes, Predicted intracellular proteins, Transcription factors | Antiviral defense, Host-virus interaction, Transcription, Transcription regulation | Activator, DNA-binding | Plasma membrane, Cytosol | |
| 0.285387576 | AKT1 | Signal transducer and activator of transcription 3 | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors | Host-virus interaction, Transcription, Transcription regulation | Activator, DNA-binding | Cancer-related genes, Diabetes mellitus, Disease mutation, Dwarfism | Nucleoplasm |
| 0.280849434 | CTNNB1 | Catenin beta 1 | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins | Cell adhesion, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation, Wnt signaling pathway | Activator | Cancer-related genes, Disease mutation, Mental retardation | Plasma membrane |
| 0.267915871 | SOD1 | Superoxide dismutase 1 | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins | Antioxidant, Oxidoreductase | Amyotrophic lateral sclerosis, Cancer-related genes, Disease mutation, Neurodegeneration | Nucleoplasm, Plasma membrane | |
| 0.267304947 | SPP1 | Secreted phosphoprotein 1 | Cancer-related genes, Plasma proteins, Predicted secreted proteins | Biomineralization, Cell adhesion | Cytokine | Cancer-related genes | Golgi apparatus |
| 0.266717153 | KRAS | KRAS proto-oncogene, GTPase | Cancer-related genes, Disease related genes, Predicted intracellular proteins, RAS pathway related proteins | Cancer-related genes, Cardiomyopathy, Deafness, Disease mutation, Ectodermal dysplasia, Mental retardation, Proto-oncogene | |||
| 0.25614674 | PTEN | Phosphatase and tensin homolog | Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins | Apoptosis, Lipid metabolism, Neurogenesis | Hydrolase, Protein phosphatase | Autism spectrum disorder, Cancer-related genes, Disease mutation, Tumor suppressor | Nucleoplasm, Cytosol |