TABLE 4.
VarElect aggregated score obtained analyzing group 3 (G3; 15 top-ranking genes).
| Normalized score | Gene | Gene description | Protein class | Biological process | Molecular function | Disease involvement | Subcellular Location |
| 1 | TBK1 | TANK Binding Kinase 1 | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins | Antiviral defense, Host-virus interaction, Immunity, Innate immunity | Kinase, Serine/threonine-protein kinase, Transferase | Amyotrophic lateral sclerosis, Disease mutation, Glaucoma, Neurodegeneration | Nucleoplasm, Vesicles |
| 0.855967078 | TNFAIP3 | TNF Alpha Induced Protein 3 | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins | Apoptosis, Inflammatory response, Ubl conjugation pathway | DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase | Cancer-related genes, Disease mutation | Vesicles |
| 0.695473251 | RANBP2 | RAN Binding Protein 2 | Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters | mRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway | RNA-binding, Transferase | Cancer-related genes | Nuclear membrane, Vesicles |
| 0.582167353 | APP | Amyloid Beta Precursor Protein | Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters | Apoptosis, Cell adhesion, Endocytosis, Notch signaling pathway | Heparin-binding, Protease inhibitor, Serine protease inhibitor | Alzheimer disease, Amyloidosis, Disease mutation, FDA approved drug targets, Neurodegeneration | Golgi apparatus; Vesicles |
| 0.573662551 | PPARG | Peroxisome Proliferator Activated Receptor Gamma | Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors | Biological rhythms, Transcription, Transcription regulation | Activator, DNA-binding, Receptor | Cancer-related genes, Diabetes mellitus, Disease mutation, FDA approved drug targets, Obesity | Nucleoplasm, Vesicles |
| 0.560219479 | GAPDH | Glyceraldehyde-3-Phosphate Dehydrogenase | Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins | Apoptosis, Glycolysis, Translation regulation | Oxidoreductase, Transferase | FDA approved drug targets | Plasma membrane, Cytosol, Vesicles |
| 0.465569273 | NEU1 | Neuraminidase 1 | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins | Carbohydrate metabolism, Lipid degradation, Lipid metabolism | Glycosidase, Hydrolase | Disease mutation | Vesicles |
| 0.456241427 | NTRK1 | Neurotrophic Receptor Tyrosine Kinase 1 | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins, RAS pathway related proteins | Differentiation, Neurogenesis | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase | Cancer-related genes, Disease mutation, FDA approved drug targets, Proto-oncogene | Vesicles, Cytosol |
| 0.438134431 | MTOR | Mechanistic Target Of Rapamycin Kinase | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins | Biological rhythms | Kinase, Serine/threonine-protein kinase, Transferase | Cancer-related genes, Disease mutation, Epilepsy, FDA approved drug targets, Mental retardation | Vesicles, Cytosol |
| 0.427160494 | LYN | LYN Proto-Oncogene, Src Family Tyrosine Kinase | Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins | Adaptive immunity, Host-virus interaction, Immunity, Inflammatory response, Innate immunity | Kinase, Transferase, Tyrosine-protein kinase | Cancer-related genes, Proto-oncogene | Golgi apparatus, Plasma membrane |
| 0.421124829 | CHUK | Component OfInhibitor Of Nuclear Factor Kappa B Kinase Complex | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins | Kinase, Serine/threonine-protein kinase, Transferase | Nucleoplasm, Vesicles, Cytosol | ||
| 0.417283951 | TPI1 | Triosephosphate Isomerase 1 | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins | Gluconeogenesis, Glycolysis | Isomerase, Lyase | Cancer-related genes, Disease mutation, Hereditary hemolytic anemia | Nucleoplasm, Vesicles |
| 0.376680384 | ATM | ATM Serine/Threonine Kinase | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins | Cell cycle, DNA damage | DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase | Cancer-related genes, Disease mutation, Neurodegeneration, Tumor suppressor | Nucleoplasm, Vesicles |
| 0.372565158 | RUNX1 | RUNX Family Transcription Factor 1 | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors | Transcription, Transcription regulation | Activator, DNA-binding, Repressor | Cancer-related genes, Disease mutation, Proto-oncogene | Nucleoplasm, Vesicles |
| 0.368998628 | BSG | Basigin (Ok Blood Group) | Blood group antigen proteins, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters | Blood group antigen | Vesicles |