TABLE 5.
VarElect aggregated score obtained analyzing group 5 related to the central nervous system (G5a; 15 top-ranking genes).
| Normalized score | Gene | Gene description | Protein class | Biological process | Molecular function | Disease involvement | Subcellular Location |
| 1 | TNF | Tumor Necrosis Factor | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins | Cytokine | Cancer-related genes, FDA approved drug targets | ||
| 0.744887478 | MAPT | Microtubule Associated Protein Tau | Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins | Alzheimer disease, Disease mutation, FDA approved drug targets, Neurodegeneration, Parkinsonism | Plasma membrane | ||
| 0.64954711 | APP | Amyloid Beta Precursor Protein | Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters | Apoptosis, Cell adhesion, Endocytosis, Notch signaling pathway | Heparin-binding, Protease inhibitor, Serine protease inhibitor | Alzheimer disease, Amyloidosis, Disease mutation, FDA approved drug targets, Neurodegeneration | Golgi apparatus, vesicles |
| 0.570314689 | APOE | Apolipoprotein E | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport | Heparin-binding | Alzheimer disease, Amyloidosis, Cancer-related genes, Disease mutation, Hyperlipidemia, Neurodegeneration | Vesicles |
| 0.534036791 | TP53 | Tumor Protein P53 | Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters | Apoptosis, Biological rhythms, Cell cycle, Host-virus interaction, Necrosis, Transcription, Transcription regulation | Activator, DNA-binding, Repressor | Cancer-related genes, Disease mutation, Li-Fraumeni syndrome, Tumor suppressor | Nucleoplasm |
| 0.530675133 | IRF3 | Interferon Regulatory Factor 3 | Disease related genes, Predicted intracellular proteins, Transcription factors | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation | Activator, DNA-binding | Disease mutation | Cytosol |
| 0.530301615 | PSEN1 | Presenilin 1 | Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters | Apoptosis, Cell adhesion, Notch signaling pathway | Hydrolase, Protease | Alzheimer disease, Amyloidosis, Cancer-related genes, Cardiomyopathy, Disease mutation, Neurodegeneration | Golgi apparatus, Nucleoplasm |
| 0.519422915 | SPTAN1 | Spectrin Alpha, Non-Erythrocytic 1 | Actin capping, Actin-binding, Calmodulin-binding | Disease mutation, Epilepsy, Mental retardation | Vesicles, Microtubules | ||
| 0.503408348 | SNCA | Alpha Synuclein | Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters | Alzheimer disease, Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism | |||
| 0.485059296 | UNC93B1 | Unc-93 Homolog B1, TLR Signaling Regulator | Adaptive immunity, Antiviral defense, Immunity, Innate immunity | Nucleoplasm | |||
| 0.48440564 | SOD1 | Superoxide Dismutase 1 | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins | Antioxidant, Oxidoreductase | Amyotrophic lateral sclerosis, Cancer-related genes, Disease mutation, Neurodegeneration | Nucleoplasm, Plasma membrane | |
| 0.441777944 | TBK1 | TANK Binding Kinase 1 | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins | Antiviral defense, Host-virus interaction, Immunity, Innate immunity | Kinase, Serine/threonine-protein kinase, Transferase | Amyotrophic lateral sclerosis, Disease mutation, Glaucoma, Neurodegeneration | Nucleoplasm, vesicles |
| 0.424596134 | TGFB1 | Transforming Growth Factor Beta 1 | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins | Growth factor, Mitogen | Cancer-related genes, Disease mutation | Golgi apparatus, Cytosol | |
| 0.420767579 | ACADM | Acyl-CoA Dehydrogenase Medium Chain | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins | Fatty acid metabolism, Lipid metabolism | Oxidoreductase | Disease mutation | Mitochondria |
| 0.41894668 | TSC2 | TSC Complex Subunit 2 | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins | Host-virus interaction | GTPase activation | Cancer-related genes, Disease mutation, Epilepsy, Tumor suppressor | Cytosol |