TABLE 6.
VarElect aggregated score obtained analyzing group 5 related to the peripheral nervous system (G5b; 15 top-ranking genes).
| Normalized score | Gene | Gene description | Protein class | Biological process | Molecular function | Disease involvement | Subcellular Location |
| 1 | NTRK1 | Neurotrophic Receptor Tyrosine Kinase 1 | Differentiation, Neurogenesis | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase | Cancer-related genes, Disease mutation, FDA approved drug targets, Proto-oncogene | Evidence at protein level | Vesicles, Cytosol |
| 0.460741389 | APOE | Apolipoprotein E | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport | Heparin-binding | Alzheimer disease, Amyloidosis, Cancer-related genes, Disease mutation, Hyperlipidemia, Neurodegeneration | Vesicles |
| 0.457968476 | MTOR | Mechanistic Target Of Rapamycin Kinase | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins | Biological rhythms | Kinase, Serine/threonine-protein kinase, Transferase | Cancer-related genes, Disease mutation, Epilepsy, FDA approved drug targets, Mental retardation | Vesicles, Cytosol |
| 0.378283713 | COMT | Catechol-O-Methyltransferase | Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins | Catecholamine metabolism, Neurotransmitter degradation | Methyltransferase, Transferase | FDA approved drug targets, Schizophrenia | Vesicles |
| 0.369819031 | APP | Amyloid Beta Precursor Protein | Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters | Apoptosis, Cell adhesion, Endocytosis, Notch signaling pathway | Heparin-binding, Protease inhibitor, Serine protease inhibitor | Alzheimer disease, Amyloidosis, Disease mutation, FDA approved drug targets, Neurodegeneration | Golgi apparatus, vesicles |
| 0.319614711 | SLC6A4 | Solute Carrier Family 6 Member 4 | Neurotransmitter transport, Symport, Transport | FDA approved drug targets | Golgi apparatus, Vesicles | ||
| 0.299036778 | PPARG | Peroxisome Proliferator Activated Receptor Gamma | Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors | Biological rhythms, Transcription, Transcription regulation | Activator, DNA-binding, Receptor | Cancer-related genes, Diabetes mellitus, Disease mutation, FDA approved drug targets, Obesity | Nucleoplasm, vesicles |
| 0.288674839 | LRRK2 | Leucine Rich Repeat Kinase 2 | Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins | Autophagy, Differentiation | GTPase activation, Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase | Cancer-related genes, Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism | Nucleoplasm, Vesicles |
| 0.26619965 | TNFAIP3 | TNF Alpha Induced Protein 3 | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins | Apoptosis, Inflammatory response, Ubl conjugation pathway | DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase | Cancer-related genes, Disease mutation | Vesicles |
| 0.260945709 | SQSTM1 | Sequestosome 1 | Disease related genes, Predicted intracellular proteins | Apoptosis, Autophagy, Differentiation, Immunity | Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration | Vesicles, Cytosol | |
| 0.24270286 | GAPDH | Glyceraldehyde-3-Phosphate Dehydrogenase | Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins | Apoptosis, Glycolysis, Translation regulation | Oxidoreductase, Transferase | FDA approved drug targets | Plasma membrane, Cytosol |
| 0.214681845 | DNM1L | Dynamin 1 Like | Biological rhythms, Endocytosis, Necrosis | Hydrolase | Disease mutation | Cytosol, Vesicles | |
| 0.193812026 | TOR1A | Torsin Family 1 Member A | Disease related genes, Predicted intracellular proteins | Chaperone, Hydrolase | Disease mutation, Dystonia | Nuclear membrane, Vesicles | |
| 0.150175131 | CAVIN1 | Caveolae Associated Protein 1 | Transcription, Transcription regulation, Transcription termination | RNA-binding, rRNA-binding | Congenital generalized lipodystrophy, Diabetes mellitus | Plasma membrane, Vesicles | |
| 0.140542907 | LDHA | Lactate Dehydrogenase A | Oxidoreductase | Cancer-related genes, Disease mutation, FDA approved drug targets, Glycogen storage disease | Cytosol, Vesicles |