Table 1.
The dynamics of miRNAs functions in adipose tissue microenvironment.
| miRNAs | Tissue | Species | Highlights | References |
|---|---|---|---|---|
| miRNA-193b/365 | BAT and WAT | Mouse | Myogenesis and adipogenesis | (48) |
| miRNA-196a | sWAT | Mouse/Human | Brown adipogenesis | (49) |
| miRNA-103 | 3T3-L1 | Mouse | Insulin signaling impairment | (50, 51) |
| miRNA-133a and miRNA-133b | BAT and sWAT | Mouse | Brown adipogenesis inhibition | (52, 53) |
| miRNA-27 | BAT and sWAT | Mouse/Human | White adipogenesis regulation; higher risk in gastric cancer | (54, 55) |
| miRNA-26a and miRNA-26b | sWAT | Human | Adipocyte differentiation; insulin signaling activation | (56, 57) |
| miRNA-145 | MSC | Mouse | Insulin stimulated AKT pathway inhibition and tumor suppressor in lung adenocarcinoma | (58, 59) |
| miRNA-34a | BAT and liver | Mouse/Human | Browning adipogenesis suppression; antitumoral role in breast cancer | (60, 61) |
| miRNA-455 | BAT and WAT | Mouse | Brown adipogenesis activation | (62) |
| miRNA-221 and miRNA-222 | SWAT/white preadipocytes | Human | Vascular Remodeling; epithelial-to mesenchymal transition activation in breast cancer | (63, 64) |
| miRNA-125b | White preadipocytes | Human | Reduction of mitochondrial biogenesis, higher risk in prostate cancer | (65, 66) |
| miRNA-320 | 3T3-L1 | Mouse | Insulin sensitivity inhibition | (67) |
| miRNA-33 | Subcutaneous Preadipocytes | Human | Lipid homeostasis regulation | (68) |
| miRNA-375 | 3T3-L1, hASCS, pancreatic islets | Mouse/human | Glucose homeostasis regulation | (69) |
| miRNA-377 | 3T3-L1 | Mouse | Adipogenesis regulation and tumor suppressor through SIRT1 inhibition | (70) |
| miRNA-21 | ADSC | Human | Adipogenic differentiation and oncogenic through a mechanism dependent on PTEN downregulation | (71, 72) |
| miRNA-155 | Brown preadipocytes | Mouse/Human | Adipogenesis, hypoxia activation and, overexpression in lung cancer | (73, 74) |
WAT, white adipose tissue; BAT, brown adipose tissue; PTEN, Phosphatase and tensin homolog; SIRT1, sirtuin 1; hASCs, human adipose tissue stem cells; MSC, adipose tissue–derived mesenchymal stem cells; ADSC, adipose tissue–derived stem cells.