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. 2020 Oct 6;11:563816. doi: 10.3389/fendo.2020.563816

Table 1.

The dynamics of miRNAs functions in adipose tissue microenvironment.

miRNAs Tissue Species Highlights References
miRNA-193b/365 BAT and WAT Mouse Myogenesis and adipogenesis (48)
miRNA-196a sWAT Mouse/Human Brown adipogenesis (49)
miRNA-103 3T3-L1 Mouse Insulin signaling impairment (50, 51)
miRNA-133a and miRNA-133b BAT and sWAT Mouse Brown adipogenesis inhibition (52, 53)
miRNA-27 BAT and sWAT Mouse/Human White adipogenesis regulation; higher risk in gastric cancer (54, 55)
miRNA-26a and miRNA-26b sWAT Human Adipocyte differentiation; insulin signaling activation (56, 57)
miRNA-145 MSC Mouse Insulin stimulated AKT pathway inhibition and tumor suppressor in lung adenocarcinoma (58, 59)
miRNA-34a BAT and liver Mouse/Human Browning adipogenesis suppression; antitumoral role in breast cancer (60, 61)
miRNA-455 BAT and WAT Mouse Brown adipogenesis activation (62)
miRNA-221 and miRNA-222 SWAT/white preadipocytes Human Vascular Remodeling; epithelial-to mesenchymal transition activation in breast cancer (63, 64)
miRNA-125b White preadipocytes Human Reduction of mitochondrial biogenesis, higher risk in prostate cancer (65, 66)
miRNA-320 3T3-L1 Mouse Insulin sensitivity inhibition (67)
miRNA-33 Subcutaneous Preadipocytes Human Lipid homeostasis regulation (68)
miRNA-375 3T3-L1, hASCS, pancreatic islets Mouse/human Glucose homeostasis regulation (69)
miRNA-377 3T3-L1 Mouse Adipogenesis regulation and tumor suppressor through SIRT1 inhibition (70)
miRNA-21 ADSC Human Adipogenic differentiation and oncogenic through a mechanism dependent on PTEN downregulation (71, 72)
miRNA-155 Brown preadipocytes Mouse/Human Adipogenesis, hypoxia activation and, overexpression in lung cancer (73, 74)

WAT, white adipose tissue; BAT, brown adipose tissue; PTEN, Phosphatase and tensin homolog; SIRT1, sirtuin 1; hASCs, human adipose tissue stem cells; MSC, adipose tissue–derived mesenchymal stem cells; ADSC, adipose tissue–derived stem cells.