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. 2020 Aug 6;4:100035. doi: 10.1016/j.yjsbx.2020.100035

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — Structural differences between apo and holo aptamer conformations. (A) Cartoon of the butterfly-shaped tertiary structure of apo-6WJR, colored by duplex regions (P1-P6), with connecting segments comprising the six-way junction colored in gray. A map of the secondary structure is shown in Fig. S1. Superimposed structures: (B) apo-6WJR (cyan), apo-2YIF (gray), and holo-2YIE (orange); (C) apo-2YIF (gray) and holo-2YIE (orange); (D) apo-6WJR (cyan) and holo-3F2Q (magenta). (E-F) Expanded views of the structural alignment shown in (D) for the opposing helical domains, P1 (E) and P4 (F), which exhibit the largest structural deviations.