Table 2.
Statistical Analysis Ofbiochemical Lab Parameters in HCC, Cirrhosis and Control Groups
| Biochemical parameters | HCC | Cirrhosis | Control | Significance test | Pairwise comparisons* |
|---|---|---|---|---|---|
| (n = 50) | (n = 25) | (n = 25) | |||
| ALT (U/L) | χ 2= 41.37 | P 1=1.000 NS | |||
| Median (IQR) | 63.50 (44.75) | 56.00 (23.50) | 26.00 (11.00) | P-value | P 2< 0.001HS |
| Range (min-max) | 11.00 - 404.00 | 31.00 - 98.00 | 11.00 - 51.00 | < 0.001HS,a | P 3< 0.001HS |
| AST (U/L) | χ 2= 42.17 | P 1=1.000NS | |||
| Median (IQR) | 67.00 (68.25) | 65.00 (37.50) | 24.00 (12.50) | P-value | P 2< 0.001HS |
| Range (min-max) | 12.00 - 534.00 | 23.00 - 243.00 | 12.00 - 49.00 | < 0.001HS,a | P 3< 0.001HS |
| Total bilirubin (mg/dL) | χ 2= 34.79 | P 1=0.213 NS | |||
| Median (IQR) | 1.65 (2.90) | 2.10 (1.45) | 0.80 (0.20) | P-value | P 2< 0.001HS |
| Range (min-max) | 0.30 - 10.00 | 1.30 - 5.20 | 0.50 - 1.30 | < 0.001HS,a | P 3< 0.001HS |
| Albumin (g/dL) | χ 2= 56.69 | P 1= 0.001HS | |||
| Median (IQR) | 3.30 (1.20) | 2.60 (0.84) | 4.30 (0.60) | P-value | P 2< 0.001HS |
| Range (min-max) | 1.90 - 4.60 | 1.70 - 3.30 | 3.70 - 5.00 | < 0.001HS,a | P 3< 0.001HS |
| INR value | χ 2=28.67 | P 1=0.153NS | |||
| Median (IQR) | 1.40 (0.60) | 1.90 (0.70) | 1.00 (0.20) | P-value | P 2< 0.001HS |
| Range (min–max) | 0.90 - 3.10 | 1.00 - 3.10 | 0.90 - 1.30 | < 0.001HS,a | P 3< 0.001HS |
| Urea (mg/dL) | χ 2 = 22.98 | P 1=1.000NS | |||
| Median (IQR) | 54.00 (22.00) | 54.00 (44.50) | 33.00 (12.50) | P-value | P 2< 0.001HS |
| Range (min–max) | 21.00 - 190.00 | 12.00 - 98.00 | 17.00 - 53.00 | < 0.001HS,a | P 3= 0.001HS |
| Creatinine (mg/dL) | χ 2 = 2.25 | – | |||
| Median (IQR) | 1.00 (0.53) | 1.10 (0.70) | 1.00 (0.20) | P-value | |
| Range (min–max) | 0.40 - 2.30 | 0.40 - 2.40 | 0.70 - 1.30 | = 0.325 NS,a | |
| RBS (mg/dL) | χ 2 = 5.40 | – | |||
| Median (IQR) | 110.00 (47.25) | 98.00 (44.00) | 105.00 (27.00) | P-value | |
| Range (min–max) | 65.00 - 364.00 | 68.00 - 243.00 | 62.00 - 145.00 | =0.067 NS,a | |
| AFP (ng/mL) | z = 4.58 | – | |||
| Median (IQR) | 62.50 (226.25) | 17.00 (16.50) | – | P-value | |
| Range (min–max) | 5.40 - 151000.00 | 3.10 - 68.00 | – | < 0.001HS,b |
IQR, Interquartile range; NS, Non significant at P-value ≥ 0.05; HS, Highly significant at P-value < 0.01; a, Kruskal-Wallis test; b, Mann-Whitney U test ; *, Multiple pairwise comparisons adjusted by Bonferronipost hoc test; P1, P-value for the difference between HCC and cirrhosis groups; P2, P-value for the difference between HCC and control groups; P3, P-value for the difference between cirrhosis and control groups.