Table 4.
Comparison of Genotype Distribution and Allele Frequencies of EGF Polymorphism (61 A/G) Inresectable versus Unresectable HCC Patients
| EGF Polymorphism 61 A/G | Resectable HCC (n = 25) | Unresectable (n = 25) | OR (95% CI) | P-value |
|---|---|---|---|---|
| Genotypes [n (%)] | ||||
| GG | 8 (32.0) | 12 (48.0) | 2.00 (0.35 - 11.44) | 0.662 NS, a |
| AG | 13 (52.0) | 10 (40.0) | 1.03 (0.19 - 5.66) | 1.000 NS, a |
| AA | 4 (16.0) | 3 (12.0) | Ref. | – |
| Dominant model1 | ||||
| GG +AG | 21 (84.0) | 22 (88.0) | 1.40 (0.28 – 7.00) | 1.000 NS, a |
| AA | 4 (16.0) | 3 (12.0) | Ref. | – |
| Recessive model2 | ||||
| GG | 8 (32.0) | 12 (48.0) | 1.96 (0.62 - 6.19) | 0.248 NS, b |
| AG+AA | 17 (68.0) | 13 (52.0) | Ref. | – |
| Alleles [n (%)] | ||||
| G | 29 (58.0) | 34 (68.0) | 1.54 (0.68 - 3.49) | 0.300 NS, b |
| A | 21 (42.0) | 16 (32.0) | Ref. | – |
a, Fisher’s Exact test; b, Pearson Chi-Square test; %, percent of genotype or allele within group; NS, Non significant at P-value ≥ 0.05; 1, Dominant model, (homozygous type + hybrid type)vs. wild type; 2, Recessive model,homozygous vs. (hybrid type+ wild type)