Table 2.
Averages of Aberrant Crypts (AC) and Aberrant Crypt Foci (ACF), in the Proximal and Distal Regions of the Colon, in Experimental Groups of Induction with DMH (1,2 dimethylhydrazine) and Essential Oil Treatment Zingiber Officinale and 5-FU
| Proximal Colon |
Distal Colon |
|||||||
|---|---|---|---|---|---|---|---|---|
| CA |
FCA |
CA |
FCA |
|||||
| 1 crypt | 2-3 crypts | 4-9 crypts | ≥10 crypts | 1 crypt | 2-3 crypts | 4-9 crypts | ≥10 crypts | |
| GI | 0.25 ±0.5 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.75±1.5 | 0.00±0.0 |
| GII | 42.67±16.20 | 36.83±16.95 | 4.83±2.63 | 0.17±0.40 | 37.50±18.29 | 47.00±15.63 | 33.33±15.16 | 0.50±0.83 |
| GIII | 40.17±22.28b | 34.17±12.44b | 1.33±1.75a | 0.00±0.0 | 18.50±11.94a,b | 28.83±13.31a | 16.67±10.55a | 0.50±0.83 |
| GIV | 8.17±5.67 | 8.17±5.03 | 2.33±2.06 | 0.00±0.0 | 7.83±3.06 | 16.00±7.72 | 16.67±8.47 | 0.50±0.83 |
| GV | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 | 0.00±0.0 |
AC, aberrant crypts; ACF, Aberrant Crypt Foci; GI, control group; GII, experimental group with DMH induction; GIII, experimental group with DMH induction + essential oil; GIV, experimental group with DMH + 5-FU induction; GV, experimental group with essential oil. Results expressed as average of the quantities observed in the animals of the same group ± standard deviation. a, Significant when compared to GII; b, Significant when compared to GIV. Significance when p<0.05.