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. 2020 Oct 19;88(11):e00071-20. doi: 10.1128/IAI.00071-20

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Copyright © 2020 Young et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — K. pneumoniae transmission between hosts with and without treatment of antibiotics. (A) A representative of 4:1 ratio of index-to-contact transmission. Four naive mice were infected orally with KPPR1S and housed with one uninfected mouse. Fecal shedding was monitored daily from both the index mouse and the contact mouse. (B) A representative of 1:4 ratio of index-to-contact transmission. One naive mouse was infected orally with KPPR1S and housed with four uninfected mice, and fecal shedding was monitored daily (C) Observed efficiency of K. pneumoniae transmission with different ratios of infected to uninfected mice, effect of antibiotics, and transmission dynamics in a metabolic cage. Statistical differences calculated using two-tailed Fisher’s exact test. In all transmission studies, fecal colonization was observed within 24 h. In 1:4 no-treatment transmission studies (n = 4), at least one successful transmission event was observed.