FIG 4.

Spatial locations of residues recognized by nine antiadhesin MAbs. (A) Residues (ball-and-stick view) within epitopes of anti-CfaE MAbs P8D10, P6C11, P6H4, P10A7, and P5C7 were mapped onto the CfaE crystal structure (ribbon and surface view; PDB code 2HB0). The receptor binding site of CfaE was located in the adhesin domain and included residues R67 and R181. (B and C) Residues within epitopes of anti-CsbD MAbs P2H6, P1F7, and P7F9 (B) and anti-CotD MAb P6B8 (C) were mapped onto the CsbD and CotD structure models, respectively.