Table 4.

Threshold Effect Analysis for the ΔPLT in the Derivation Cohort Using a Two-Piece-Wise Cox Proportional Hazards Model

	Unadjusted HR (95% CI)	Adjusted HR (95% CI)#
The one-line Cox proportional hazards model	1.00 (0.97, 1.03)	1.02 (0.99, 1.05)
The two-piece-wise Cox proportional hazards model
<0 (20×109/L)	0.95 (0.92, 0.98)	0.98 (0.94, 1.02)
≥0 (20×109/L)	1.12 (1.06, 1.18)	1.08 (1.03, 1.14)
P for log-likelihood ratio test	<0.001	0.013

Notes: A log-likelihood ratio test was used to compare the one-line linear regression. ^#This model was adjusted for age (<55, ≥55), PS score (0, 1), Child-Pugh class (A, B, NA), diameter of main tumour (<5, ≥5), location of lesions (none, left/right, both), No. of intrahepatic lesions (0, ≤3, >3), CRP (<10, ≥10, NA) and AFP (<25, ≥25, NA).