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. 2020 Oct 15;22(11):644–658. doi: 10.1016/j.neo.2020.07.001

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Fbxw7⁻^/⁻ tumors are highly proliferative and apoptotic. A. Representative results of H&E staining showing normal breast architecture in a control Fbxw7^+/+ animal and excessive filling of the fat pad and epithelial proliferation in two independent Fbxw7⁻^/⁻ tumors. B. Representative IHC results showing Ki67 staining (marking proliferation), which is low in control tissues and high in tumors. C. Representative IHC results for cleaved caspase 3 marking increased apoptosis in tumors. Little apoptosis was observed in control animals. All images 400×.