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An overview of PET approaches to investigating changes in LC dysfunction in neurodegenerative disorders. (A,B) Tau and NET PET can be used to assess pathological load and LC fiber integrity by imaging downstream brain regions in healthy and disease states. (C,D) Imaging the LC using tau and NET PET can also be informative of pathological load and cell body integrity in healthy and disease states. Blue arrows represent LC-NE release sites throughout the brain and spinal cord.
