Table 2.

Results of meta-regression analyses for MDD and BD.

Group	Region	Peak MNI coordinate (x, y, z)	No. of voxels	SDM-Z value	p value
MDD	Effect of HAMD score
	Abnormal activities in studies with higher HAMD score
	Right anterior cingulate/paracingulate gyri, BA 32	6, 44, 28	32	1.70	2.27e−4
	Right median cingulate/paracingulate gyri, BA 23	4, −36, 36	123	−1.64	1.34e−4
BD	Effect of illness duration
	Abnormal activities in studies with longer illness duration
	Right anterior thalamic projections	16, 2, 16	131	2.51	2.58e−5
	Right striatum	28, −4, −6	20	−2.46	1.86e−4
	Effect of HAMD score
	Abnormal activities in studies with higher HAMD score
	Right posterior cingulate gyrus, BA 23	2, −50, 30	303	−2.98	<e−10
	Effect of YMRS score
	Abnormal activities in studies with higher YMRS score
	Right insula, BA 48	42, 10, −2	1133	5.38	<e−10
	Right inferior frontal gyrus, orbital part, BA 47	40, 44, −2	345	3.44	7.74e−5
	Left insula, BA 48	−36, 14, 8	231	4.34	<e−10
	Right amygdala, BA 34	22, −2, −10	67	2.87	4.23e−4
	Right superior frontal gyrus, BA 10	14, 46, 0	46	3.92	5.19e−6
	Left cerebellum	−26, −80, −24	839	−4.41	<e−10
	Right precuneus, BA 5	4, −52, 58	325	−3.11	1.03e−4

MDD major depressive disorder, BD bipolar disorder, HAMD Hamilton depression scale, YMRS Young Manic Rating Scale, BA Brodmann area, MNI Montreal Neurological Institute, SDM seed-based d mapping.