Table 3.
Symptoms and diagnostic findings.
| Admission day (n = 33) | Follow up (n = 33) | |
|---|---|---|
|
Symptoms | ||
| - Fever | 22 (67%) | 1 (3%) |
| - Cough | 23 (70%) | 11 (33%) |
| - Dyspnea | 16 (48%) | 11 (33%) |
| - Fatigue | 21 (64%) | 15 (45%) |
| - Tiredness | 18 (55%) | 15 (45%) |
| - Hemoptysis | 1 (3%) | 0 (0%) |
| - Rhinorrhea | 2 (6%) | 4 (12%) |
| - Sore throat | 8 (24%) | 3 (9%) |
| - Pharyngalgia | 4 (12%) | 0 (0%) |
| - Angina pectoris | 4 (12%) | 6 (18%) |
| - Myalgia | 12 (42%) | 5 (15%) |
| - Headache | 7 (21%) | 5 (15%) |
| - Cognitive disorders | – | 6 (18%) |
| - Loss of Smell | 8 (24%) | 4 (12%) |
| - Loss of Taste | 9 (27%) | 3 (9%) |
| Gastrointestinal symptoms | 17 (52%) | 3 (9%) |
| - Diarrhea | 13 (39%) | 3 (9%) |
| - Nausea | 8 (24%) | 2 (6%) |
| - Emesis | 2 (6%) | 0 (0%) |
| - Stomach pains |
7 (21%) |
1 (3%) |
|
Examination and vital parameters | ||
| Height, cm | 172 {165–178} | 172 {165–178} |
| Weight, kg | 83 {71–95} | 83 {72–97} |
| BMI, kg/m2 | 28 {24-31} | 29 {24-31} |
| Respiratory rate, bpm | 20 {18-23} | 16 {15-18} |
| Oxygen saturation, % | 94 {90–97} | 98 {97–99} |
| Needing oxygen therapy, n (%) | 27 (82%) | 1 (3%) |
| Oxygen flow, l/min | 0 {0–2} | – |
| Temperature, °C | 38 {37-39} | 36,6 {36,5-36,9} |
| Systolic BP, mmHg | 126 {110–139} | 140 {126–152} |
| Diastolic BP, mmHg | 76 {66–80} | 89 {79–100} |
| Heart rate, bpm | 90 {80–102} | 80 {72–89} |
| Frailty Score |
– |
3 {3-4} |
|
Pulmonary function parameters and ABGs | ||
| - TLC, % of predicted | – | 94 {85–105} |
| - VC, % of predicted | – | 93 {78–101} |
| - RV, % of predicted | – | 112 {98–127} |
| - RV/TLC, % of predicted | – | 109 {98–126} |
| - FEV1, % of predicted | – | 95 {72–103} |
| - FEV1/FVC, % | – | 79 {76–85} |
| - R eff, % of predicted | – | 86 {62–104} |
| - DLCO, % of predicted | – | 65 {53–73} |
| - DLCO/VA, % of predicted |
– |
77 {69–95} |
|
ABG | ||
| - paO 2, mmHg | – | 72 {67_79} |
| - paCO 2, mmHg | – | 38 {35_38} |
| - pH | – | 7.4 {7.4_7.4} |
| - Base excess, mmol/l | – | 0.8 {-0.6_+1.2} |
| - COHb, vol% |
– |
0.9 {0.7_1} |
|
6MWT | ||
| - Distance, m | – | 380 {180_470} |
| - Distance < predicted value, n | – | 26 (79%) |
| - Distance < LLN, n | – | 15 (45%) |
| - Walk distance - predicted value, m | – | −138 {-37_-191} |
| - Walk distance - LLN, m | – | 1.5 {-52_+130} |
| - SpO2 before exercise, % | – | 97 {94_98} |
| - SpO2 after exercise, % | – | 96 {94_98} |
| - HR before exercise, bpm | – | 76 {61_86} |
| - HR after exercise, bpm | – | 91 {74_100} |
| - Dyspnea on Borg scale before exercise | – | 0 {0_2} |
| - Dyspnea on Borg scale after exercise | – | 1 {0_4} |
| - Fatigue on Borg scale before exercise | – | 1 {0_3} |
| - Fatigue on Borg scale after exercise |
– |
1 {0_4} |
|
Echocardiography | ||
| - LVEF - global normal | 17/18 (94%) | 29/33 (88%) |
| - LVEF, % | 54 {42–55} | 52 {50–52} |
| - RVEF - global normal | 17/18 (94%) | 31/33 (94%) |
| - TAPSE, mm | – | 20 {18-23} |
| - RVEDD, mm | – | 37 {33-40} |
| - RVSP + CVP, mmHg |
– |
25 {22-31} |
|
Virologic diagnostic | ||
| - SARS-CoV-2 RNA - positive | 33 (100%) | 0 (0%) |
| - SARS-CoV-2 IgG – positive | – | 30 (91%) |
| - SARS-CoV-2 IgG (quant.) | – | 7.9 {4.8–9.9} |
Values are presented as number of patients (percentage) or median {interquartile range}.
ABBREVIATIONS: ABGs = arterial blood gases; BP = Blood pressure; CVP = central venous pressure; DLco = diffusing capacity for carbon monoxide; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; HR = heart rate; IgG = immunoglobulin G; LLN = lower limit of normal, LVEF = left ventricular ejection fraction; PaCO2 = partial pressure of carbon dioxide; PaO2 = partial pressure of oxygen; Reff = effective specific resistance; RNA = ribonucleic acid; RV = residual volume; RVEDD = right ventricular end-diastolic dimension; RVEF = right ventricular ejection fraction; RVSP = right Ventricular Systolic Pressure; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; SpO2, oxygen saturation; TAPSE = tricuspid annular plane systolic excursion; TLC = total lung capacity; VA = alveolar volume; VC = vital capacity.